Two sample MR report
PLA2G16_Endothelial Cell (Endo) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | -0.0612082 | 0.2034799 | 0.8139815 |
| Weighted median | 3 | -0.0403614 | 0.0165307 | 0.0146222 |
| Inverse variance weighted | 3 | -0.0394445 | 0.0136499 | 0.0038557 |
| Simple mode | 3 | -0.0411002 | 0.0194031 | 0.1683237 |
| Weighted mode | 3 | -0.0412478 | 0.0189932 | 0.1620157 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0302397 | 1 | 0.8619475 |
| Inverse variance weighted | 0.0417313 | 2 | 0.9793505 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0160581 | 0.1497977 | 0.9320147 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.43e-05 | 0 | TRUE | 0.4140459 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
